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Chemical Structure : NSC348884
CAS No.: 81624-55-7
Catalog No.: PC-20788Not For Human Use, Lab Use Only.
NSC348884 is a small molecule nucleophosmin (NPM) inhibitor, disrupts the formation of dimers and inhibits aberrant NPM functionin cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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NSC348884 is a small molecule nucleophosmin (NPM) inhibitor, disrupts the formation of dimers and inhibits aberrant NPM functionin cancer cells.
NSC348884 inhibits cell proliferation at an IC(50) of 1.7-4.0 uM in distinct cancer cell lines and disrupts NPM oligomer formation by native polyacrylamide gel electrophoresis assay.
NSC348884 upregulates p53 (increased Ser15 phosphorylation) and induces apoptosis in a dose-dependent manner that correlated with apoptotic markers: H2AX phosphorylation, poly(ADP-ribose) polymerase cleavage and Annexin V labeling.
NSC348884 synergizes doxorubicin cytotoxicity on cancer cell viability.
| M.Wt | 636.81 | |
| Formula | C38H40N10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
CC1=CC=C2N=C(CN(CC3=NC4=CC=C(C)C=C4N3)CCN(CC5=NC6=CC=C(C)C=C6N5)CC7=NC8=CC=C(C)C=C8N7)NC2=C1 |
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1. Qi W, et al. Oncogene. 2008 Jul 10;27(30):4210-20.
2. Balusu R, et al. Blood. 2011 Sep 15;118(11):3096-106.
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