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Chemical Structure : NSC373981
Catalog No.: PC-49195Not For Human Use, Lab Use Only.
NSC373981 (NSC 373981) is a CARD11 G-quadruplex (G4) stabilizing small molecule that downregulates CARD11 gene expression in DLBCL cells.
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NSC373981 (NSC 373981) is a CARD11 G-quadruplex (G4) stabilizing small molecule that downregulates CARD11 gene expression in DLBCL cells.
NSC373981 dose-dependent repression of CARD11 mRNA levels in both ABC DLBCL cells, RIVA and HBL1, and the GCB DLBCL cell.
NSC373981 requires nitro-group for CARD11 G-quadruplex (G4) stabilization and repression of CARD11 transcription.
NSC373981 concurrently represses the expression of BCL2 and MYC, two other key oncogenes in DLBCL.
| M.Wt | 257.245 | |
| Formula | C14H11NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kennith Swafford, et al. Genes (Basel). 2022 Jun 25;13(7):1144.
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