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Chemical Structure : NSC45586
CAS No.: 6300-44-3
Catalog No.: PC-60663Not For Human Use, Lab Use Only.
NSC45586 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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NSC45586 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2.
NSC45586 also inhibits PHLPP2, has no activities against other phosphatases.
NSC45586 activates AKT and ameliorates staurosporine-induced cell death in neurons.
| M.Wt | 412.385 | |
| Formula | C20H17N6NaO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
benzoic acid, 5-[2-[4-[2-(2,4-diamino-5-methylphenyl)diazenyl]phenyl]diazenyl]-2-hydroxy-,sodium salt |
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1. Jackson TC, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.
2. Sierecki E, et al. J Med Chem. 2010 Oct 14;53(19):6899-911.
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