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Chemical Structure : NSC49652
Catalog No.: PC-35729Not For Human Use, Lab Use Only.
NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells.
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NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells; induces apoptosis through p75NTR and the JNK pathway in neurons and affects the viability of melanoma cells, reduces tumor growth and improves survival in human melanoma xenograft model, orally available.
| M.Wt | 225.247 | |
| Formula | C14H11NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Goh ETH, et al. Cell Chem Biol. 2018 Oct 1. pii: S2451-9456(18)30302-7.
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