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Chemical Structure : NSC49L
Catalog No.: PC-49084Not For Human Use, Lab Use Only.
NSC49L (NSC30049) is a small molecule agonist (activator) of protein phosphatase 2A (PP2A), specifically stimulates PP2A-Cα activity with Kact of 14 nM, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation.
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NSC49L (NSC30049) is a small molecule agonist (activator) of protein phosphatase 2A (PP2A), specifically stimulates PP2A-Cα activity with Kact of 14 nM, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation.
NSC49L (NSC30049) interacts with the catalytic subunit C of the PP2A and stimulates its activity.
NSC49L (NSC30049) treatment increases the colocalization of eIF4E with unphosphorylated 4EBP1 and inhibits p21 protein synthesis in FOLFOX-HT29 cells.
Caspase 3 inhibitor ZDEVD reverses the cytotoxic effect of NSC49L and TRAIL in FOLFOX-HT29 cells.
NSC49L (NSC30049) induces TRAIL/caspase-3-dependent apoptosis of FOLFOX-resistant CRC cells.
NSC49L (NSC30049) also inhibited Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.
NSC49L (NSC30049) showed very potent activity in a HDTX model of CRC stem cell tumors either alone or in combination with 5-FU.
| M.Wt | 265.182 | |
| Formula | C10H18Cl2N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Narayan S, et al. Oncotarget. 2017 Aug 1;8(34):57246-57264.
2. Narayan S, et al. iScience. 2022 Jun 3;25(7):104518.
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