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Chemical Structure : NSC 87877
CAS No.: 56990-57-9
Catalog No.: PC-61176Not For Human Use, Lab Use Only.
NSC 87877 is potent, selective protein tyrosine phosphatase SHP1 and SHP2 with IC50 of 318 and 355 nM, respectively, also inhibits dual-specificity phosphatase 26 (DUSP26).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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NSC 87877 is potent, selective protein tyrosine phosphatase SHP1 and SHP2 with IC50 of 318 and 355 nM, respectively, also inhibits dual-specificity phosphatase 26 (DUSP26).
NSC 87877 displays 5-fold selectivity over PTP1B, 20-fold over HePTP and no activity against DEP1, CD45 and LAR.
NSC 87877 also effectively inhibits DUSP26-mediated dephosphorylation of p38.
NSC 87877 inhibits EGF-induced activation of Shp2 PTP, Ras, and Erk1/2 in cell cultures, inhibits EGFRvIII oncogenic transformation in human glioblastoma cells.
| M.Wt | 459.45 | |
| Formula | C19H13N3O7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid |
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1. Chen L, et al. Mol Pharmacol. 2006 Aug;70(2):562-70.
2. Langdon YG, et al. Development. 2007 Nov;134(22):4119-30.
3. Song M, et al. Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.
4. Zhan Y, et al. Exp Cell Res. 2009 Aug 15;315(14):2343-57.
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