Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NSC95397
CAS No.: 93718-83-3
Catalog No.: PC-60248Not For Human Use, Lab Use Only.
NSC95397 is a potent, selective, reversible Cdc25 dual specificity phosphatase inhibitor with Ki of 32/96/40 nM for Cdc25A/B/C, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NSC95397 is a potent, selective, reversible Cdc25 dual specificity phosphatase inhibitor with Ki of 32/96/40 nM for Cdc25A/B/C, respectively.
NSC95397 displays 125- and 180-fold selectivity over VH1-related dual-specificity phosphatase and PTP1B.
NSC95397 shows significant growth inhibition in cancer cells and blocks G(2)/M phase transition.
NSC95397 also inhibits cellular MKP-1 and MKP-3 with IC50 of 13 uM.
| M.Wt | 310.38 | |
| Formula | C14H14O4S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone |
|
1. Lazo JS, et al. Mol Pharmacol. 2002 Apr;61(4):720-8.
2. Nemoto K, et al. Prostate. 2004 Jan 1;58(1):95-102.
3. Vogt A, et al. Mol Cancer Ther. 2008 Feb;7(2):330-40.
4. Larsson DE, et al. Anticancer Res. 2010 Jan;30(1):149-56.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
