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Chemical Structure : NUP-17d-52A
Catalog No.: PC-49704Not For Human Use, Lab Use Only.
NUP-17d-52A (Plek2 inhibitor) is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2-DEP domain with high affinity (Kd=160 nM).
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NUP-17d-52A (Plek2 inhibitor) is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2-DEP domain with high affinity (Kd=160 nM).
NUP-17d-52A has IC50 of 4.52 µM in the erythroid in vitro proliferation assays against bone marrow lineage negative cells.
NUP-17d-52A also significantly inhibited enucleation and differentiation of the cultured erythroid cells and induced apoptosis.
Pleckstrin-2 (Plek2) is a downstream target of the JAK2-STAT pathway and overexpressed in patients with myeloproliferative neoplasms (MPNs), Plek2 activates Akt and protects Akt through Hsp72.
| M.Wt | 362.86 | |
| Formula | C21H19ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu Han, et al. J Clin Invest. 2023 Jan 31;e159638.
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