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NUP214 degrader 0449-b

Chemical Structure : NUP214 degrader 0449-b

CAS No.:

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NUP214 degrader 0449-b

Catalog No.: PC-27930Not For Human Use, Lab Use Only.

NUP214 degrader 0449-b is a selective nucleoporin NUP214 degrader by recruiting NUP214 to the Cullin5-Rbx2 E3 ligase complex, induces NUP214 neddylation and proteasomal degradation, triggers leukemia stem cells (LSCs) ferroptosis and exhibits anti-leukemic activity, while sparing normal hematopoietic stem cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NUP214 degrader 0449-b is a selective nucleoporin NUP214 degrader by recruiting NUP214 to the Cullin5-Rbx2 E3 ligase complex, induces NUP214 neddylation and proteasomal degradation, triggers leukemia stem cells (LSCs) ferroptosis and exhibits anti-leukemic activity, while sparing normal hematopoietic stem cells.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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