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Chemical Structure : NVP-231
CAS No.: 362003-83-6
Catalog No.: PC-20871Not For Human Use, Lab Use Only.
NVP-231 (NVP231) is a potent, specific, and reversible ceramide kinase (CerK) inhibitor with IC50 of 12 nM.
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NVP-231 (NVP231) is a potent, specific, and reversible ceramide kinase (CerK) inhibitor with IC50 of 12 nM.
NVP-231 does not compete with ATP but rather with ceramide, displaying an inhibition constant (Ki) of 7.4 nM.
NVP-231 inhibits C1P formation with IC50 of <10 nM in human CerK-overexpressing COS-cells (COS-CerK), achieved complete inhibition at 100 nM.
NVP-231 also is a potent inhibitor of mouse CerK.
NVP-231 does not inhibit sphingosine kinases and other lipid kinases, including phosphatidylinositol-3 kinase, phosphatidylinositol-4 kinase β, and Vps34.
When combined with another ceramide metabolizing inhibitor, such as tamoxifen, NVP-231 synergistically increased ceramide levels and reduced cell growth.
| M.Wt | 431.55 | |
| Formula | C25H25N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide |
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1. Graf C, et al. Mol Pharmacol. 2008 Oct;74(4):925-32.
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