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Chemical Structure : NVP-BSK805
CAS No.: 1092499-93-8
Catalog No.: PC-44039Not For Human Use, Lab Use Only.
NVP-BSK805 is a potent, selective and ATP-competitive inhibitor of JAK2 (V617F) and wt JAK2 (IC50=0.5 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NVP-BSK805 is a potent, selective and ATP-competitive inhibitor of JAK2 (V617F) and wt JAK2 (IC50=0.5 nM).
NVP-BSK805 displays >20-fold selectivity towards JAK1, JAK3, TYK2 and excellent selectivity in broader kinase profiling.
NVP-BSK805 blunts constitutive STAT5 phosphorylation in JAK2(V617F)-bearing cells.
NVP-BSK805 exhibits good oral bioavailability and a long half-life.
| M.Wt | 490.5476 | |
| Formula | C27H28F2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Quinoxaline, 8-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- |
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1. Baffert F, et al. Mol Cancer Ther. 2010 Jul;9(7):1945-55.
2. Pissot-Soldermann C, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2609-13.
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