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NVS-VHL097

Chemical Structure : NVS-VHL097

CAS No.: 1448188-69-9

NVS-VHL097 (VL285 Phenol)

Catalog No.: PC-25284Not For Human Use, Lab Use Only.

NVS-VHL097 (VL285 Phenol) is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 111 nM, binds with VHL (binary) with SPR KD of 68 nM, induces CDO1 degradation (absDC50 of 349 nM/77% degradation) in HEK293T cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NVS-VHL097 (VL285 Phenol) is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 111 nM, binds with VHL (binary) with SPR KD of 68 nM, induces CDO1 degradation (absDC50 of 349 nM/77% degradation) in HEK293T cells.

Physicochemical Properties

M.Wt 532.66
Formula C29H32N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

References

1. Tutter A, et al. Nat Chem Biol. 2025 Jun 24. doi: 10.1038/s41589-025-01936-x.

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