Chemical Structure : NVS-VHL097
CAS No.: 1448188-69-9
Catalog No.: PC-25284Not For Human Use, Lab Use Only.
NVS-VHL097 (VL285 Phenol) is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 111 nM, binds with VHL (binary) with SPR KD of 68 nM, induces CDO1 degradation (absDC50 of 349 nM/77% degradation) in HEK293T cells.
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NVS-VHL097 (VL285 Phenol) is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 111 nM, binds with VHL (binary) with SPR KD of 68 nM, induces CDO1 degradation (absDC50 of 349 nM/77% degradation) in HEK293T cells.
M.Wt | 532.66 | |
Formula | C29H32N4O4S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
1. Tutter A, et al. Nat Chem Biol. 2025 Jun 24. doi: 10.1038/s41589-025-01936-x.
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