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Chemical Structure : NaV1.7 inhibitor 51
Catalog No.: PC-72207Not For Human Use, Lab Use Only.
NaV1.7 inhibitor 51 is a highly potent, selective, orally active NaV1.7 inhibitor with IC50 of 10.7 nM in FLIPR membrane potential assay, no significant activity against NaV1.5 (IC50>10 uM).
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NaV1.7 inhibitor 51 is a highly potent, selective, orally active NaV1.7 inhibitor with IC50 of 10.7 nM in FLIPR membrane potential assay, no significant activity against NaV1.5 (IC50>10 uM).
NaV1.7 inhibitor 51 shows good selectivity against other NaV isoforms and minimal inhibition at 10 uM for the resting state across different NaV isoforms.
NaV1.7 inhibitor 51 exhibits state-dependent block of human, monkey, and mouse NaV1.7 with a similar potency range.
NaV1.7 inhibitor 51 shows significant effects on the CCI-induced neuropathic pain model.
| M.Wt | 499.512 | |
| Formula | C24H20F3N5O2S | |
| Appearance | Solid | |
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1. Vidya Ramdas, et al. J Med Chem. 2020 Jun 11;63(11):6107-6133.
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