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Chemical Structure : Naphthyridine-azaquinolone
Catalog No.: PC-73136Not For Human Use, Lab Use Only.
Naphthyridine-azaquinolone (NA) is a specific small molecule that specifically binds slipped-CAG DNA intermediates of expansion mutations.
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Naphthyridine-azaquinolone (NA) is a specific small molecule that specifically binds slipped-CAG DNA intermediates of expansion mutations.
Naphthyridine-azaquinolone specifically inhibits repair of long CAG slip-outs by human (HeLa) cell extracts.
Naphthyridine-azaquinolone modulates instability of expanded mutant repeats in Huntington's disease (HD) cells, with limited off-target effects.
NA induces CAG contractions, independent of proliferation, dependent on rCAG transcription, affects interaction of DNA repair proteins on long CAG slip-outs.
Naphthyridine-azaquinolone modulates repeat instability in the striatum of HD mice, induces a reduction in mHTT aggregates in R6/2 mice.
Naphthyridine-azaquinolone-induced contractions depend upon active expansions driven by MutSβ.
| M.Wt | 459.51 | |
| Formula | C24H25N7O3 | |
| Appearance | Solid | |
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1. Nakamori M, et al. Nat Genet. 2020 Feb;52(2):146-159.
2. Hasuike Y, et al. Neurobiol Dis. 2022 Feb;163:105604.
3. Deshmukh AL, et al. Cell Rep. 2021 Dec 7;37(10):110078.
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