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Chemical Structure : Naquotinib mesylate
CAS No.: 1448237-05-5
Catalog No.: PC-45722Not For Human Use, Lab Use Only.
Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Naquotinib (ASP-8273) mesylateis a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).
Naquotinib (ASP-8273) is more potently than that of WT EGFR (IC50= 230 nM).
Naquotinib (ASP-8273) shows activity in mutant EGFR cell line which is resistant to other EGFR TKIs including AZD9291 and CO-1686.
| M.Wt | 658.812 | |
| Formula | C31H46N8O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 12.5 mg/mL |
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| Chemical Name/SMILES |
2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-, methanesulfonate (1:1) |
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1. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.
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