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Chemical Structure : Narlaprevir
CAS No.: 865466-24-6
Catalog No.: PC-42515Not For Human Use, Lab Use Only.
A potent, second generation HCV NS3 serine protease inhibitor with Ki of 6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $723.2 | In stock | |
| 100 mg | $1264 | In stock |
Bulk size, bulk discount!
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A potent, second generation HCV NS3 serine protease inhibitor with Ki of 6 nM; displays no significant issues in the in vitro CYP or hERG assay; shows replicon EC90 of 40 nM; exhibits improved potency (∼10-fold over Boceprevir), pharmacokinetic profile and physicochemical characteristics.
| M.Wt | 707.9639 | |
| Formula | C36H61N5O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Azabicyclo[3.1.0]hexane-2-carboxamide, N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]pentyl]-3-[(2S)-2-[[[[1-[[(1,1-dimethylethyl)sulfonyl]methyl]cyclohexyl]amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-, (1R,2S,5S)- |
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1. Arasappan A, et al. ACS Med Chem Lett. 2010 Feb 15;1(2):64-9.
2. Tong X, et al. Antimicrob Agents Chemother. 2010 Jun;54(6):2365-70.
3. de Bruijne J, et al. Hepatology. 2010 Nov;52(5):1590-9.
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