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Chemical Structure : Nek1 inhibitor 10f
Catalog No.: PC-72831Not For Human Use, Lab Use Only.
Nek1 inhibitor 10f is a potent, selective NIMA-related kinase 1 (Nek1) inhibitor with IC50 of 330 nM.
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Nek1 inhibitor 10f is a potent, selective NIMA-related kinase 1 (Nek1) inhibitor with IC50 of 330 nM.
Nek1 inhibitor 10f displayed insignificant inhibition in 48 of 50 kinases in a selectivity test panel.
Nek1 has lately garnered attention for its widespread function in ciliogenesis, apoptosis, and the DNA-damage response.
Administration of Nek1 inhibitor 10f caused the expansion of fluorescence-labeled proximal convoluted tubules. Nek1-inhibition causes cystic kidneys in zebrafish embryos of zebrafish polycystic kidney disease model.
| M.Wt | 446.525 | |
| Formula | C24H22N4O3S | |
| Appearance | Solid | |
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1. Georg Baumann, et al. J Med Chem. 2022 Jan 27;65(2):1265-1282.
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