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Nesbuvir

Chemical Structure : Nesbuvir

CAS No.: 691852-58-1

Nesbuvir (HCV-796, HCV796)

Catalog No.: PC-20275Not For Human Use, Lab Use Only.

Nesbuvir (HCV-796) is a selective, non-nucleoside HCV nonstructural protein 5B (NS5B) polymerase inhibitor with IC50 of 0.01-0.14 uM for genotype 1, EC50 of 5 nM and 9 nM against genotype 1a and 1b replicon.

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Biological Activity

Nesbuvir (HCV-796) is a selective, non-nucleoside HCV nonstructural protein 5B (NS5B) polymerase inhibitor with IC50 of 0.01-0.14 uM for genotype 1, EC50 of 5 nM and 9 nM against genotype 1a and 1b replicon.
Nesbuvir (HCV-796) showed slow binding kinetics to NS5B with Kd of 71 nM.
Nesbuvir (HCV-796) reduced HCV RNA levels by 3 to 4 log(10) HCV copies/mug total RNA with IC50 of 9 nM in hepatoma cells containing a genotype 1b HCV replicon
Nesbuvir (HCV-796) treatment cuased a 2.02 +/- 0.55 log reduction in HCV titer in the chimeric mouse model.

Physicochemical Properties

M.Wt 446.49
Formula C22H23FN2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-3-benzofurancarboxamide

References

1. Howe AY, et al. Antimicrob Agents Chemother. 2008 Sep;52(9):3327-38.

2. McCown MF, et al. Antimicrob Agents Chemother. 2008 May;52(5):1604-12.

3. Norman M Kneteman, et al. Hepatology. 2009 Mar;49(3):745-52.

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