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Chemical Structure : Nimbolide
CAS No.: 25990-37-8
Catalog No.: PC-21374Not For Human Use, Lab Use Only.
Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping.
Nimbolide treatment is synthetically lethal in BRCA-deficient tumor cells.
Nimbolide is also able to kill BRCA-deficient tumor cells with intrinsic and acquired resistance to conventional PARPi.
Nimbolide has significant bactericidal activity against H. pylori, killing both free living bacterial cells as well as cells within a biofilm.
Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling.
| M.Wt | 466.53 | |
| Formula | C27H30O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate |
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1. Li P, et al. Sci Adv. 2023 Oct 27;9(43):eadg7752.
2. Mehmetoglu-Gurbuz T, et al. Antioxidants (Basel). 2023 Sep 22;12(10):1791.
3. Wylie MR, et al. J Ethnopharmacol. 2022 Mar 1;285:114828.
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