Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : OATD-01
CAS No.: 2088453-21-6
Catalog No.: PC-38628Not For Human Use, Lab Use Only.
OATD-01 (GLPG4716) is a highly potent, orally active chitotriosidase (CHIT1) inhibitor with IC50 of 26 (hCHIT1) and 29 nM (mCHIT1), inhibits hAMCase and mAMCase with IC50 of 9.0 and 7.8 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
OATD-01 (GLPG4716) is a highly potent, orally active chitotriosidase (CHIT1) inhibitor with IC50 of 26 (hCHIT1) and 29 nM (mCHIT1), inhibits hAMCase and mAMCase with IC50 of 9.0 and 7.8 nM, respectively.
OATD-01 poseeses binding affinity values for hCHIT1 (Ki=17.3 nM), mCHIT1 (Ki=26.05 nM), hAMCase (Ki= 4.8 nM), mAMCase (Ki=5.7 nM), and displays no inhibition against a panel of 98 targets in in vitro binding and enzymatic assays.
OATD-01 (30 and 100 mg/kg, p.o. q.d.) showed significant antifibrotic efficacy in an animal model of bleomycin-induced pulmonary fibrosis (IPF), decreased expression of profibrotic factors in lung tissues and reduced fibrosis and soluble collagen concentration.
| M.Wt | 390.916 | |
| Formula | C19H27ClN6O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-(4-((2S,5S)-5-(4-Chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-4H-1,2,4-triazol-3-amine |
|
1. Koralewski R, et al. J Med Chem. 2020 Dec 24;63(24):15527-15540.
2. Sklepkiewicz P, et al. Eur J Pharmacol. 2022 Mar 15;919:174792.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
