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OB756

Chemical Structure : OB756

CAS No.: 2119040-02-5

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OB756 (Bonretinib, OB-756)

Catalog No.: PC-25681Not For Human Use, Lab Use Only.

OB756 (Bonretinib) is a potent, selective, oral JAK2 kinase inhibitor, inhibits cell proliferation and induces cell apoptosis, significantly inhibits the phosphorylation activity of p-STAT3 in the JAK-STAT signaling pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OB756 (Bonretinib) is a potent, selective, oral JAK2 kinase inhibitor, inhibits cell proliferation and induces cell apoptosis, significantly inhibits the phosphorylation activity of p-STAT3 in the JAK-STAT signaling pathway.

    Physicochemical Properties

    M.Wt 399.47
    Formula C18H21N7O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)piperidin-4-yl)acetonitrile

    References

    1. Yile Zhou MD, et al. Blood. Volume 144, Supplement 1, 5 November 2024, Page 1808.

    2. Jian Huang, et al. Cancer. 2025 Oct 15;131(20):e70101.

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