OB756 (Bonretinib)

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Chemical Structure : OB756

Catalog No.: PC-25681Not For Human Use, Lab Use Only.

OB756 (Bonretinib) is a potent, selective, oral JAK2 kinase inhibitor, inhibits cell proliferation and induces cell apoptosis, significantly inhibits the phosphorylation activity of p-STAT3 in the JAK-STAT signaling pathway.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OB756 (Bonretinib) is a potent, selective, oral JAK2 kinase inhibitor, inhibits cell proliferation and induces cell apoptosis, significantly inhibits the phosphorylation activity of p-STAT3 in the JAK-STAT signaling pathway.

Physicochemical Properties

M.Wt	399.47
Formula	C18H21N7O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)piperidin-4-yl)acetonitrile

References

1. Yile Zhou MD, et al. Blood. Volume 144, Supplement 1, 5 November 2024, Page 1808.

2. Jian Huang, et al. Cancer. 2025 Oct 15;131(20):e70101.

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