OMDM-1 is a potent, selective inhibitor of anandamide cellular uptake (ACU) with Ki of 2.4 uM, inhibits anandamide transport.
OMDM-1 shows poor affinity for either CB(1) (K(i)>5 uM) or CB(2) (K(i)>10 uM) receptors in rat brain and spleen membranes.
OMDM-1 also shows no activity at vanilloid receptors in the intracellular calcium assay carried out with intact cells over-expressing the human VR1 (EC(50)> or = 10 micro M), and no activity as inhibitors of FAAH in N18TG2 cell membranes.
