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ONL1204

Chemical Structure : ONL1204

CAS No.: 2040964-58-5

ONL1204 (ONL-1204, Xelafaslatide)

Catalog No.: PC-24946Not For Human Use, Lab Use Only.

ONL1204 (Xelafaslatide) is a small peptide inhibitor of the Fas receptor, blocks Fas death receptor signaling and prevents mFasL-induced apoptosis.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ONL1204 (Xelafaslatide) is a small peptide inhibitor of the Fas receptor, blocks Fas death receptor signaling and prevents mFasL-induced apoptosis.
ONL1204 rescues A20 B lymphoma cells from FasL-mediated apoptosis.
ONL1204 protects RGCs and prevents axon degeneration in the microbead-induced model of glaucoma.
ONL1204 shows protective effect in distinct mouse models of retinal degeneration.

Physicochemical Properties

M.Wt 1461.69
Formula C71H100N18O16
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Tyrosinamide, L-histidyl-L-histidyl-L-isoleucyl-L-tyrosyl-L-leucylglycyl-L-alanyl-L-valyl-L-asparaginyl-L-tyrosyl-L-isoleucyl-

References

1. Krishnan A, et al. J Neuroinflammation. 2019 Sep 30;16(1):184.

2. Yang M, et al. Cell Death Dis. 2024 Aug 8;15(8):576.

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