Chemical Structure : ONL1204
CAS No.: 2040964-58-5
Catalog No.: PC-24946Not For Human Use, Lab Use Only.
ONL1204 (Xelafaslatide) is a small peptide inhibitor of the Fas receptor, blocks Fas death receptor signaling and prevents mFasL-induced apoptosis.
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ONL1204 (Xelafaslatide) is a small peptide inhibitor of the Fas receptor, blocks Fas death receptor signaling and prevents mFasL-induced apoptosis.
ONL1204 rescues A20 B lymphoma cells from FasL-mediated apoptosis.
ONL1204 protects RGCs and prevents axon degeneration in the microbead-induced model of glaucoma.
ONL1204 shows protective effect in distinct mouse models of retinal degeneration.
M.Wt | 1461.69 | |
Formula | C71H100N18O16 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
L-Tyrosinamide, L-histidyl-L-histidyl-L-isoleucyl-L-tyrosyl-L-leucylglycyl-L-alanyl-L-valyl-L-asparaginyl-L-tyrosyl-L-isoleucyl- |
1. Krishnan A, et al. J Neuroinflammation. 2019 Sep 30;16(1):184.
2. Yang M, et al. Cell Death Dis. 2024 Aug 8;15(8):576.
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