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Chemical Structure : ONO-7579
Catalog No.: PC-72113Not For Human Use, Lab Use Only.
ONO-7579 (ONO7579) is a novel potent, selective, orally available pan-TRK inhibitor.
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ONO-7579 (ONO7579) is a novel potent, selective, orally available pan-TRK inhibitor.
BDNF significantly increased TRKB phosphorylation in GBC cells and the effects were abrogated by ONO-7579, suppress proliferation in a dose-dependent manner in TYGBK-1 cells.
ONO-7579 inhibited BDNF/TRKB-induced migration and invasiveness, particularly in GBC cells harboring wild-type KRAS.
ONO-7579 reduced invasiveness of gallbladder cancer (GBC) cells through inhibiting epithelial–mesenchymal transition (EMT) via the extracellular signal-regulated kinase (ERK) or protein kinase B (AKT) pathway.
| M.Wt | 578.951 | |
| Formula | C24H18ClF3N6O4S | |
| Appearance | Solid | |
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1. Kawamoto M, et al. Anticancer Res. 2018 Apr;38(4):1979-1986.
2. Iida H, et al. J Pharmacol Exp Ther. 2020 Jun;373(3):361-369.
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