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Chemical Structure : OP-5244
Catalog No.: PC-72269Not For Human Use, Lab Use Only.
OP-5244 is a highly potent, orally bioavailable CD73 inhibitor with biochemical IC50 of 0.25 nM.
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OP-5244 is a highly potent, orally bioavailable CD73 inhibitor with biochemical IC50 of 0.25 nM.
OP-5244 inhibited adenosine production in both human cancer cells and CD8+ T cells.
OP-5244 lowered the ratio of ADO/AMP significantly and reversed immunosuppression in mouse models.
| M.Wt | 537.891 | |
| Formula | C19H29ClN5O9P | |
| Appearance | Solid | |
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1. Xiaohui Du, et al. J Med Chem. 2020 Sep 24;63(18):10433-10459.
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