ORIC-533 | CD73 inhibitor | Probechem Biochemicals

Chemical Structure : ORIC-533

ORIC-533 (ORIC533)

Catalog No.: PC-24616Not For Human Use, Lab Use Only.

ORIC-533 is a potent, selective, AMP-competitive and orally bioavailable ectonucleotidase CD73 inhibitor.

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Biological Activity

ORIC-533 is a potent, selective, AMP-competitive and orally bioavailable ectonucleotidase CD73 inhibitor.
ORIC-533 decreases adenosine generation, overcomes immune suppression, and restores immune cell-mediated MM cell lysis.
ORIC-533 induces autologous MM cell killing in MM BM-MNCs in a dose-dependent manner.
ORIC-533 activates MM-BM pDCs in the MM bone marrow microenvironment.
ORIC-533 induces NK cell-mediated cytotoxicity in MM and enhances autologous MM cell killing in combination with Daratumumab.

Physicochemical Properties

M.Wt	605.93
Formula	C20H29ClN9O9P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-chloro-N-cyclopentyl-1-[5-O-[(1S)-1-(hydroxymethyl)-1-phosphono-2-(2H-tetrazol-5-ylmethoxy)ethyl]-β-D-ribofuranosyl]-

References

1. Arghya Ray, et al. Blood Cancer J. 2024 Apr 9;14(1):58.

ORIC-533 (ORIC533)

Biological Activity

Physicochemical Properties

References

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