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Chemical Structure : OSI-930
CAS No.: 728033-96-3
Catalog No.: PC-42449Not For Human Use, Lab Use Only.
A potent, orally active, dual inhibitor of c-Kit and VEGFR-2 (KDR) with IC50 of 15 nM and 9 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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OSI-930 is a potent, orally active, dual inhibitor of c-Kit and VEGFR-2 (KDR) with IC50 of 15 nM and 9 nM, respectively.
OSI-930 also inhibits Lck, c-Raf, Flt1, and CSF-1R (IC50<100 nM).
OSI-930 exhibits antitumor activity in mutant Kit-expressing HMC-1 xenograft model.
| M.Wt | 443.4416 | |
| Formula | C22H16F3N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Thiophenecarboxamide, 3-[(4-quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]- |
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1. Garton AJ, et al. Cancer Res. 2006 Jan 15;66(2):1015-24.
2. Yap TA, et al. Clin Cancer Res. 2013 Feb 15;19(4):909-19.
3. Patel JP, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6495-9.
4. Macpherson IR, et al. Eur J Cancer. 2013 Mar;49(4):782-9.
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