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OSM-SMI-10B

Chemical Structure : OSM-SMI-10B

CAS No.: 2502294-55-3

OSM-SMI-10B (SMI-10B)

Catalog No.: PC-20489Not For Human Use, Lab Use Only.

OSM-SMI-10B (SMI-10B) is a first-in-class small molecule inhibitor binds to oncostatin M (OSM) with Kd of 13.6 uM, significantly reduces OSM-induced STAT3 phosphorylation in cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OSM-SMI-10B (SMI-10B) is a first-in-class small molecule inhibitor binds to oncostatin M (OSM) with Kd of 13.6 uM, significantly reduces OSM-induced STAT3 phosphorylation in cancer cells.

Physicochemical Properties

M.Wt 378.34
Formula C21H14O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(O)/C=C/C1=CC(C2=CC=C(OCO3)C3=C2)=C(C4=CC=C(OCO5)C5=C4)O1

References

1. Olga A Mass, et al. Sci Rep. 2021 Aug 10;11(1):16174.

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