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Chemical Structure : OT-82
Catalog No.: PC-38153Not For Human Use, Lab Use Only.
OT-82 (NAMPT inhibitor OT-82) is a novel selective and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), reduces the viability of leukemia cells with IC50 of 0.2-4 nM.
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OT-82 (NAMPT inhibitor OT-82) is a novel selective and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), reduces the viability of leukemia cells with IC50 of 0.2-4 nM.
Similar to the leukemia cell lines, the PDX cells were highly sensitive to OT-82 treatment with IC50 values ranging from 0.4 to 3.6 nM.
OT-82 exerts its antileukemic action by reducing cellular NAD+ and inducing apoptosis.
OT-82 induces significant leukemia regression in vivo in a large panel of ALL PDXs derived from high-risk and poor outcome pediatric patients.
| M.Wt | 424.479 | |
| Formula | C26H21FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Teicher B, et al. Leukemia. 2020 Jun;34(6):1524-1539.
2. Korotchkina L, et al. Leukemia. 2020 Jul;34(7):1828-1839.
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