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Chemical Structure : Olesoxime
Catalog No.: PC-62134Not For Human Use, Lab Use Only.
Olesoxime (TRO 19622) is a cholesterol-like compound that binds directly to two components of the mitochondrial permeability transition pore: the voltage-dependent anion channel and TSPO (or PBR).
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Olesoxime (TRO 19622) is a cholesterol-like compound that binds directly to two components of the mitochondrial permeability transition pore: the voltage-dependent anion channel and TSPO (or PBR); rescues motor neurons from axotomy-induced cell death in neonatal rats and promoted nerve regeneration following sciatic nerve crush in vivio, significantly reduces established mechano-allodynia and mechano-hyperalgesia.
Spinal Muscular Atrophy (SMA)
Phase 3 Clinical
| M.Wt | 399.65 | |
| Formula | C27H45NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bordet T, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):709-20.
2. Schaller S, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):696-706.
3. Sunyach C, et al. Neuropharmacology. 2012 Jun;62(7):2346-52.
4. Gouarné C, et al. Br J Pharmacol. 2013 Apr;168(8):1975-88.
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