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Omapatrilat

Chemical Structure : Omapatrilat

CAS No.: 167305-00-2

Omapatrilat (BMS-186716)

Catalog No.: PC-45435Not For Human Use, Lab Use Only.

A potent, dual inhibitor of the metalloproteases ACE and NEP with Ki of 0.64 nM and 0.45 nM, respectively.

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Biological Activity

A potent, dual inhibitor of the metalloproteases ACE and NEP with Ki of 0.64 nM and 0.45 nM, respectively; shows moderate activity against APP, and low activity against ECE1; causes significant inhibition of plasma ACE and increases plasma renin activity, reduces blood pressure in spontaneously hypertensive rats; orally active.

Hypertension

Discontinued

Physicochemical Properties

M.Wt 408.5349
Formula C19H24N2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

7H-Pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-, (4S,7S,10aS)-

References

1. Robl JA, et al. J Med Chem. 1997 May 23;40(11):1570-7.

2. Fryer RM, et al. Br J Pharmacol. 2008 Mar;153(5):947-55.

3. Burrell LM, et al. Am J Hypertens. 2000 Oct;13(10):1110-6.

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