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Cat. No. Product Name CAS No. Information
PC-60710

Gemopatrilat

160135-92-2 A potent, orally available, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 12 and 63 nM, respectively; causes prolonged inhibition of circulating and renal ACE and renal NEP after a single oral dose in atherogenic diet rabbits.

Heart Failure

Phase 2 Discontinued

PC-60709

Ilepatril

669764-02-7 A potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively; displays good in vitro selectivity over a large variety of targets; restores endothelial function by increasing the ratio of NO to O2- concentration and bioavailability of NO, prevents albuminuria and reduces the incidence and severity of glomerulosclerosis and tubulointerstitial damage in vivo.

Hypertension

Phase 2 Discontinued

PC-45435

Omapatrilat

167305-00-2 A potent, dual inhibitor of the metalloproteases ACE and NEP with Ki of 0.64 nM and 0.45 nM, respectively; shows moderate activity against APP, and low activity against ECE1; causes significant inhibition of plasma ACE and increases plasma renin activity, reduces blood pressure in spontaneously hypertensive rats; orally active.

Hypertension

Discontinued

PC-45434

Lisinopril dihydrate

83915-83-7 A angiotensin-converting enzyme (ACE) inhibitor for treatment of hypertension, heart failure, and after heart attacks.

Hypertension

Approved

PC-45433

Lisinopril

76547-98-3 A angiotensin-converting enzyme (ACE) inhibitor for treatment of hypertension, heart failure, and after heart attacks.

Hypertension

Approved

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