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Chemical Structure : Opiranserin
Catalog No.: PC-60526Not For Human Use, Lab Use Only.
Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM).
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Opiranserin (VVZ-149, VVZ-000149) is a potent, selective, mixed glycine GlyT2 transporter blocker (IC50= 0.86 uM), purine P2X3 receptor antagonist (IC50=0.87 uM) and serotonin 5-HT2A receptor antagonist (IC50=1.3 uM); demonstrates analgesic efficacy for postoperative pain.
Pain
Phase 2 Clinical
| M.Wt | 394.512 | |
| Formula | C21H34N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nedeljkovic SS, et al. BMJ Open. 2017 Feb 17;7(2):e011035.
2. Oh J, et al. J Clin Pharmacol. 2018 Jan;58(1):64-73.
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