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Chemical Structure : Oridonin
CAS No.: 28957-04-2
Catalog No.: PC-35078Not For Human Use, Lab Use Only.
Oridonin is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Oridonin is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK.
Oridonin is an active diterpenoid compound isolated from the plant Rabdosia Rrubescens, has various pharmacological activities, including antioxidant, anti-tumor capacities and anti-inflammation.
Oridonin inhibits AKT kinase activity (AKT1 and AKT2 IC50=8.4 and 8.9 uM) and interacts with the ATP-binding pocket of AKT, inhibits growth of ESCC in vitro and patient derived xenografts in vivo.
Oridonin inhibits vascular inflammation by blocking NF-κB and MAPK activation.
| M.Wt | 364.438 | |
| Formula | C20H28O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Kaur-16-en-15-one, 7a,20-epoxy-1a,6b,7,14-tetrahydroxy-, (14R)- (8CI) |
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1. Song M, et al. Mol Cancer Ther. 2018 Apr 25. pii: molcanther.0823.2017.
2. Kadioglu O, et al. Front Pharmacol. 2018 Apr 16;9:355.
3. Huang W, et al. Eur J Pharmacol. 2018 May 5;826:133-139.
4. Zhang HP, et al. Oncotarget. 2017 Oct 16;8(63):106833-106843.
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