Chemical Structure : Orniplabin
CAS No.:
733805-92-0
Orniplabin
(SMTP-7, Lemuplamor, Stachybotrys microspora triprenylphenol 7)
Catalog No.: PC-28510Not For Human Use, Lab Use Only.
Orniplabin (SMTP-7, Lemuplamor, Stachybotrys microspora triprenylphenol-7) is a fungal triprenyl phenol metabolite and plasminogen modulator, shows thrombolytic and anti-inflammatory effects, inhibits soluble epoxide hydrolase (sEH) to suppress inflammation, inhibits Cterm-EH and the Nterm-phos of sEH with IC50 of 23 uM and 6 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Orniplabin (SMTP-7, Lemuplamor, Stachybotrys microspora triprenylphenol-7) is a fungal triprenyl phenol metabolite and plasminogen modulator, shows thrombolytic and anti-inflammatory effects, inhibits soluble epoxide hydrolase (sEH) to suppress inflammation, inhibits Cterm-EH and the Nterm-phos of sEH with IC50 of 23 uM and 6 uM.
Physicochemical Properties
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M.Wt
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869.11
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Formula
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C51H68N2O10
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2,5-bis((2R,3S)-2-((E)-4,8-dimethylnona-3,7-dien-1-yl)-3,5-dihydroxy-2-methyl-7-oxo-3,4,7,9-tetrahydropyrano[2,3-e]isoindol-8(2H)-yl)pentanoic acid
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References
1. Matsumoto N, et al. J Biol Chem. 2014 Dec 26;289(52):35826-38.
2. Hu W, et al. Thromb J. 2012 Jan 9;10(1):2.
3. Shibata K, et al. Naunyn Schmiedebergs Arch Pharmacol. 2011 Jul;384(1):103-8.
4. Shibata K, et al. Naunyn Schmiedebergs Arch Pharmacol. 2010 Sep;382(3):245-53.
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