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Chemical Structure : Orvepitant
Catalog No.: PC-61552Not For Human Use, Lab Use Only.
Orvepitant (GW823296) is a potent and selective, brain penetrant NK1 receptor antagonist with pKi of 10.2.
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Orvepitant (GW823296) is a potent and selective, brain penetrant NK1 receptor antagonist with pKi of 10.2; exhibits an excellent, dose dependent inhibition of foot tapping in gerbils after oral administration with an ID50 of 0.11 mg/kg; shows antidepressant effects.
Depression
Phase 2 Clinical
| M.Wt | 628.623 | |
| Formula | C31H35F7N4O2 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Di Fabio R, et al. Bioorg Med Chem. 2013 Nov 1;21(21):6264-73.
2. Ratti E, et al. J Psychopharmacol. 2013 May;27(5):424-34.
3. Trower MK, et al. Exp Dermatol. 2014 Nov;23(11):858-60.
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