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Chemical Structure : Oxythiamine chloride hydrochloride
CAS No.: 614-05-1
Catalog No.: PC-63371Not For Human Use, Lab Use Only.
Oxythiamine chloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $68 | In stock | |
| 250 mg | $98 | In stock | |
| 1 g | $148 | In stock |
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Oxythiamine chloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM; Oxythiamine induces G1 arrest in Ehrlich’s ascites tumor cells implanted in mice.
| M.Wt | 338.247 | |
| Formula | C12H17Cl2N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-((4-hydroxy-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride hydrochloride |
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1. Thomas AA, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2206-10.
2. Tseng CW, et al. Cancer Res. 2018 Mar 29. pii: canres.2906.2017.
3. Ricciardelli C, et al. Clin Exp Metastasis. 2015 Jun;32(5):441-55.
4. Raïs B, et al. FEBS Lett. 1999 Jul 30;456(1):113-8.
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