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Chemical Structure : P053
Catalog No.: PC-35607Not For Human Use, Lab Use Only.
P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6.
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P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6.
P053 (P-053, CerS1 inhibitor P053) selectively reduces C18 sphingolipids in cultured cells, with no effect on HEK293 cell viability at or below 1 uM.
P053 (P-053, CerS1 inhibitor P053) increases fatty acid oxidation in skeletal muscle and impedes increases in muscle triglycerides and adiposity in mice fed a HFD, but does not protect against HFD-induced insulin resistance.
P053 (P-053, CerS1 inhibitor P053) increases palmitate oxidation and mitochondrial respiratory capacity in SkM.
| M.Wt | 354.271 | |
| Formula | C18H21Cl2NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Turner N, et al. Nat Commun. 2018 Aug 21;9(1):3165.
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