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Chemical Structure : P217564
Catalog No.: PC-62574Not For Human Use, Lab Use Only.
P 217564 is a potent, selective, irreversible second generation inhibitor of USP7 with IC50 of 0.48 uM, with similar potency against USP47 and no significant activity aginst other DUBs.
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P217564 is a potent, selective, irreversible second generation inhibitor of USP7 with IC50 of 0.48 uM, with similar potency against USP47 and no significant activity aginst other DUBs.
P217564 exhibits 10-fold increase in potency compared to P5091, selectively targets the catalytic cleft of USP7 and modifies its active site cysteine (C223) by forming a covalent adduct.
P217564 downregulates Foxp3 and Tip60 in Treg cells and impairs Treg functions, increases polyubiquitination of Foxp3, Tip60 and USP7, induces dose- and time-dependent apoptosis of Jurkat cells.
| M.Wt | 447.3 | |
| Formula | C16H12Cl2N2O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang F, et al. PLoS One. 2017 Dec 13;12(12):e0189744.
2. Wang L, et al. EBioMedicine. 2016 Nov;13:99-112.
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