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PAPTP

Chemical Structure : PAPTP

CAS No.: 2176486-17-0

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PAPTP

Catalog No.: PC-62646Not For Human Use, Lab Use Only.

PAPTP is a PAP-1 derivative, potent, specific Kv1.3 channel inhibitor with IC50 of 31 nM in Jurkat T lymphocytes by patch-clamp, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PAPTP is a PAP-1 derivative, potent, specific Kv1.3 channel inhibitor with IC50 of 31 nM in Jurkat T lymphocytes by patch-clamp, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.
    PAPTP kills 98% of ex vivo primary chronic B-lymphocytic leukemia tumor cells while sparing healthy B cells.
    PAPTP significantly reduces tumor size in orthotopic mouse models of melanoma and pancreatic ductal adenocarcinoma.

    Physicochemical Properties

    M.Wt 780.639
    Formula C42H38IO5P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-(4-(4-((7-oxo-7H-furo[3,2-g]chromen-4-yl)oxy)butoxy)phenyl)propyl)triphenylphosphonium iodide

    References

    1. Leanza L, et al. Cancer Cell. 2017 Apr 10;31(4):516-531.e10.

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