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Chemical Structure : PARPYnD
Catalog No.: PC-72910Not For Human Use, Lab Use Only.
PARPYnD is the first cell-active photoaffinity probe (AfBP) for PARP protein class, based on triple PARP1/2/6 inhibitor AZ9482.
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PARPYnD is the first cell-active photoaffinity probe (AfBP) for PARP protein class, based on triple PARP1/2/6 inhibitor AZ9482.
PARPYnD is a robust tool for profiling PARP1/2 and is used to profile clinical PARP inhibitor olaparib, identifying several novel off-target proteins.
PARPYnD can enrich recombinant PARP6 spiked into cellular lysates and inhibits PARP6 in cell-free assays, it does not label PARP6 in intact cells.
PARPYnD inhibits PARP1/2/6 with IC50 of 38/6/230 nM, respectively.
| M.Wt | 613.68 | |
| Formula | C34H31N9O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ryan T Howard, et al. ACS Chem Biol. 2020 Feb 21;15(2):325-333.
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