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Chemical Structure : PAT1inh-A0030
Catalog No.: PC-21358Not For Human Use, Lab Use Only.
PAT1inh-A0030 is a potent and selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor with IC50 of 1.0 uM, shows no activity on relevant ion transporters/channels (SLC26A3, SLC26A4, SLC26A9, CFTR, TMEM16A).
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PAT1inh-A0030 is a potent and selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor with IC50 of 1.0 uM, shows no activity on relevant ion transporters/channels (SLC26A3, SLC26A4, SLC26A9, CFTR, TMEM16A).
PAT1inh-A0030 inhibited fluid absorption in the ileum of wild-type and CF mice (CftrdelF508/delF508) with >90% prevention of a decrease in loop fluid volume and loop weight/length ratio in a closed-loop model of intestinal fluid absorption.
| M.Wt | 326.36 | |
| Formula | C17H18N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tifany Chu, et al. RSC Med Chem. 2023 Sep 14;14(11):2342-2347.
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