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Chemical Structure : PAT1inh-B01
Catalog No.: PC-38753Not For Human Use, Lab Use Only.
PAT1inh-B01 is a small-molecule, selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor, could fully inhibit PAT1-mediated anion exchange with IC50 of 350 nM.
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PAT1inh-B01 is a small-molecule, selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor, could fully inhibit PAT1-mediated anion exchange with IC50 of 350 nM.
PAT1inh-B01 displays no inhibition of the related intestinal transporter SLC26A3 (also known as DRA).
In closed midjejunal loops in mice, PAT1inh-B01 inhibited fluid absorption by 50%, which increased to >90% when coadministered with DRA inhibitor DRAinh-A270.
PAT1inh-B01 blocked fluid absorption by >80% in ileal loops, SLC26A3 inhibitor DRAinh-A270 had no effect.
PAT1inh-B01 is a novel tool to study intestinal ion and fluid transport.
| M.Wt | 535.325 | |
| Formula | C22H18BrF3N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cil O, et al. JCI Insight. 2021 Jun 8;6(11):e147699.
2. Lee S, et al. J Med Chem. 2019;62(17):8330–8337.
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