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Chemical Structure : PAX inhibitor BG1
Catalog No.: PC-72554Not For Human Use, Lab Use Only.
PAX inhibitor BG1 (PAX-IN-BG1) is a small molecule that attenuate Pax-2 transactivation ability with IC50 of 1.5 uM.
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PAX inhibitor BG1 (PAX-IN-BG1) is a small molecule that attenuate Pax-2 transactivation ability with IC50 of 1.5 uM.
BG1 also shows ability to inhibit Pax5 and Pax8 activation of the PRS4-Luc reporter assays.
BG1 inhibits Pax2-positive cancer cell growth and target gene expression but has little effect on Pax2-negative cells.
BG1 prevent Pax protein interactions with the histone H3K4 methylation complex at Pax target genes (Cdh6) in renal cells.
| M.Wt | 336.443 | |
| Formula | C19H24N6 | |
| Appearance | Solid | |
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1. Shayna T J Bradford, et al. Cell Chem Biol. 2021 Nov 18;S2451-9456(21)00480-3.
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