Chemical Structure : PCI-27483
CAS No.:
Catalog No.: PC-25822Not For Human Use, Lab Use Only.
PCI-27483 is a potent and selective inhibitor of the serine protease Factor VIIa (FVIIa) in complex with tissue factor (TF), also inhibits human carbonic anhydrase IX and XII (hCA IX and XII) with IC50 of 35.7 nM and 4.7 nM, also is a potential Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=1.41 uM) for antiviral of SARS-CoV-2.
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|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
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PCI-27483 is a potent and selective inhibitor of the serine protease Factor VIIa (FVIIa) in complex with tissue factor (TF), also inhibits human carbonic anhydrase IX and XII (hCA IX and XII) with IC50 of 35.7 nM and 4.7 nM, also is a potential Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=1.41 uM) for antiviral of SARS-CoV-2.
| M.Wt | 596.57 | |
| Formula | C26H24N6O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2-(5-(6-Carbamimidoyl-1H-benzo[d]imidazol-2-yl)-2',6-dihydroxy-5'-sulfamoyl-[1,1'-biphenyl]-3-yl)acetyl)-L-aspartic acid |
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1. D'Agostino I, et al. ACS Med Chem Lett. 2024 Oct 21;15(11):2042-2045.
2. Ramanathan RK, et al. Oncology. 2019;96(4):217-222.
3. Shrimp JH, et al. ACS Infect Dis. 2022 Jun 10;8(6):1191-1203.

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