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PCI-27483

Chemical Structure : PCI-27483

CAS No.:

PCI-27483 (PCI 27483)

Catalog No.: PC-25822Not For Human Use, Lab Use Only.

PCI-27483 is a potent and selective inhibitor of the serine protease Factor VIIa (FVIIa) in complex with tissue factor (TF), also inhibits human carbonic anhydrase IX and XII (hCA IX and XII) with IC50 of 35.7 nM and 4.7 nM, also is a potential Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=1.41 uM) for antiviral of SARS-CoV-2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PCI-27483 is a potent and selective inhibitor of the serine protease Factor VIIa (FVIIa) in complex with tissue factor (TF), also inhibits human carbonic anhydrase IX and XII (hCA IX and XII) with IC50 of 35.7 nM and 4.7 nM, also is a potential Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=1.41 uM) for antiviral of SARS-CoV-2.

Physicochemical Properties

M.Wt 596.57
Formula C26H24N6O9S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2-(5-(6-Carbamimidoyl-1H-benzo[d]imidazol-2-yl)-2',6-dihydroxy-5'-sulfamoyl-[1,1'-biphenyl]-3-yl)acetyl)-L-aspartic acid

References

1. D'Agostino I, et al. ACS Med Chem Lett. 2024 Oct 21;15(11):2042-2045.

2. Ramanathan RK, et al. Oncology. 2019;96(4):217-222.

3. Shrimp JH, et al. ACS Infect Dis. 2022 Jun 10;8(6):1191-1203.

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