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Chemical Structure : PD-184352
CAS No.: 212631-79-3
Catalog No.: PC-45828Not For Human Use, Lab Use Only.
PD-184352 (CI-1040) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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PD-184352 (CI-1040) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5.
PD-184352 reduces pMAPK levels in multiple tumor cells, prevents cell cycle progression and induces G1 block.
PD-184352 suppresses growth of colon tumors in vivo.
| M.Wt | 478.6595 | |
| Formula | C17H14ClF2IN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 150 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro- |
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1. Sebolt-Leopold JS, et al. Nat Med, 1999, 5(7), 810-816.
2. Davies SP, et al. Biochem J, 2000, 135(1), 95-105.
3. Pellicano F, et al. Leukemia, 2011, 25(7), 1159-1167.
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