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PD-321852

Chemical Structure : PD-321852

CAS No.: 622856-21-7

PD-321852 (PD 321852;PD321852)

Catalog No.: PC-60286Not For Human Use, Lab Use Only.

PD-321852 is a potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PD-321852 is a  potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
    PD-321852 potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines.
    PD-321852 inhibits gemcitabine-induced Rad51 focus formation, and depletes RAD51 proteins in pancreatic cancer cells.

    Physicochemical Properties

    M.Wt 468.33
    Formula C24H19Cl2N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(methylamino)propyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

    References

    1. Parsels LA, et al. Mol Cancer Ther. 2009 Jan;8(1):45-54.

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