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Chemical Structure : PD0325901
CAS No.: 391210-10-9
Catalog No.: PC-42489Not For Human Use, Lab Use Only.
PD0325901 is a selective, non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 100 mg | $188 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PD0325901 is a selective, non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
PD0325901 markedly inhibits ERK phosphorylation and growth of both BRAF mutant and wild-type melanoma cell lines with IC50 in the nanomolar range.
PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo; orally active.
| M.Wt | 482.1931 | |
| Formula | C16H14F3IN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 56 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- |
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1. Barrett SD, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4.
2. Ciuffreda L, et al. Neoplasia. 2009 Aug;11(8):720-31.
3. Henderson YC, et al. Mol Cancer Ther. 2010 Jul;9(7):1968-76.
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