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Chemical Structure : PD153035 hydrochloride
CAS No.: 183322-45-4
Catalog No.: PC-42828Not For Human Use, Lab Use Only.
PD153035 (ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271) is a highly potent, specific, ATP-competitive EGFR inhibitor with IC50 of 0.025 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $318 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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PD153035 (ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271) is a highly potent, specific, ATP-competitive EGFR inhibitor with IC50 of 0.025 nM; inhibits EGF-dependent EGF receptor phosphorylation and suppresses the proliferation and clonogenicity of a wide panel of EGF receptor-overexpressing human cancer cell lines (IC50<1 uM); rapidly suppresses phosphorylation of the EGF receptor in A431 human epidermoid tumors grown as xenografts in immunodeficient nude mice.
| M.Wt | 396.6662 | |
| Formula | C16H15BrClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1) |
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1. Bridges AJ, et al. J Med Chem. 1996 Jan 5;39(1):267-76.
2. Bos M, et al. Clin Cancer Res. 1997 Nov;3(11):2099-106.
3. Fry DW, et al. Science. 1994 Aug 19;265(5175):1093-5.
4. Kunkel MW, et al. Invest New Drugs. 1996;13(4):295-302.
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