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Chemical Structure : PDDC
CAS No.: 2232878-43-0
Catalog No.: PC-72748Not For Human Use, Lab Use Only.
PDDC is the first potent, selective, orally-available, and brain-penetrable nSMase2 (neutral sphingomyelinase 2) inhibitor with pIC50 of 6.57.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $248 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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PDDC is the first potent, selective, orally-available, and brain-penetrable nSMase2 (neutral sphingomyelinase 2) inhibitor with pIC50 of 6.57.
PDDC inhibited release of ADEVs in tissue culture and in vivo, capable of dose-dependently reducing EVs release in vitro and in vivo.
PDDC reduced these IL-1β-induced changes implicating nSMase2 inhibition as a therapeutic target for acute brain injury.
| M.Wt | 487.56 | |
| Formula | C27H29N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)carbamate |
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1. Rojas C, et al. Br J Pharmacol. 2019 Oct;176(19):3857-3870.
2. Šála M, et al. J Med Chem. 2020 Jun 11;63(11):6028-6056.
3. Tallon C, et al. Biochem Pharmacol. 2021 Dec;194:114796.
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